Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct Delivery of Recombinant Pin1 Protein Rescued Osteoblast Differentiation of Pin1-Deficient Cells.

Journal of cellular physiology - 1 Oct 2017

Kim Woo-Jin, Islam Rabia, Kim Bong-Soo, Cho Young-Dan, Yoon Won-Joon, Baek Jeong-Hwa, Woo Kyung-Mi, Ryoo Hyun-Mo

Abstract excerpt

Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of several proteins. We reported that Pin1 plays a critical role in the fate determination of Smad1/5, Runx2, and β-catenin that are indispensable nuclear proteins for osteoblast differentiation. Though several chemical inhibitors has been discovered for Pin1, no activator has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 1 Subunit
Share to Delayed-Action Preparations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Carriers

Share to Nanoparticles

Share to NIMA-Interacting Peptidylprolyl Isomerase

Share to Osteoblasts

Share to Osteogenesis

Share to Smad1 Protein

Source

Identifiers

PMID: 27800612
DOI: 10.1002/jcp.25673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct Delivery of Recombinant Pin1 Protein Rescued Osteoblast Differentiation of Pin1-Deficient Cells.PMID 27800612Read ↗

Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.Semantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Pin1-mediated Runx2 modification is critical for skeletal development.Semantic proximity Read ↗

Targeting Pin1 for Modulation of Cell Motility and Cancer TherapySemantic proximity Read ↗

Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future DirectionsSemantic proximity Read ↗

Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.Semantic proximity Read ↗

Targeting carcinogenesis: A role for the prolyl isomerase Pin1?Semantic proximity Read ↗

Small molecules targeting Pin1 as potent anticancer drugsSemantic proximity Read ↗

The role of Pin1 protein in aging of human tendon stem/progenitor cellsSemantic proximity Read ↗

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.Semantic proximity Read ↗

Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells.Semantic proximity Read ↗

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.