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Article

Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.

The Journal of biological chemistry - 29 Jan 2010

Fujimoto Yoshito, Shiraki Takuma, Horiuchi Yuji, Waku Tsuyoshi, Shigenaga Akira, Otaka Akira, Ikura Tsuyoshi, Igarashi Kazuhiko, Aimoto Saburo, Tate Shin-ichi, Morikawa Kosuke

Abstract excerpt

The important roles of a nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) are widely accepted in various biological processes as well as metabolic diseases. Despite the worldwide quest for pharmaceutical manipulation of PPARgamma activity through the ligand-binding domain, very little information about the activation mechanism of the N-terminal activation function-1 (AF-1) domain....

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Identifiers

PMID: 19996102
DOI: 10.1074/jbc.M109.055095
PMCID: PMC2823398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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