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Article

Small molecules targeting Pin1 as potent anticancer drugs

27 Mar 2023

Abstract excerpt

Background: Pin1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family of proteins. Following phosphorylation, Pin1-catalyzed prolyl-isomerization induces conformational changes, which serve to regulate the function of many phosphorylated proteins that play important roles during oncogenesis. Thus, the inhibition of Pin1 provides a unique means of disrupting oncogenic pathways and...

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Identifiers

PMID: 37050909
DOI: 10.3389/fphar.2023.1073037

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