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Article

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

Molecular and cellular biology - 1 Aug 2002

Ryo Akihide, Liou Yih-Cherng, Wulf Gerburg, Nakamura Masafumi, Lee Sam W, Lu Kun Ping

Abstract excerpt

Oncogenes Neu/HER2/ErbB2 and Ras can induce mammary tumorigenesis via upregulation of cyclin D1. One major regulatory mechanism in these oncogenic signaling pathways is phosphorylation of serines or threonines preceding proline (pSer/Thr-Pro). Interestingly, the pSer/Thr-Pro motifs in proteins exist in two completely distinct cis and trans conformations, whose conversion is catalyzed specifically by the essential...

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Source

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Identifiers

PMID: 12101225
DOI: 10.1128/MCB.22.15.5281-5295.2002
PMCID: PMC133940

Genes

PIN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.PMID 12101225Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.Semantic proximity Read ↗

Targeting carcinogenesis: A role for the prolyl isomerase Pin1?Semantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.Semantic proximity Read ↗

Targeting Pin1 for Modulation of Cell Motility and Cancer TherapySemantic proximity Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

PIN1 in breast development and cancer: a clinical perspectiveSemantic proximity Read ↗

Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancerSemantic proximity Read ↗

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