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Article

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.

The EMBO journal - 18 Aug 2004

Wulf Gerburg, Garg Priti, Liou Yih-Cherng, Iglehart Dirk, Lu Kun Ping

Abstract excerpt

Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 is prevalently overexpressed in human cancers and implicated in oncogenesis. However, the role of Pin1 in oncogenesis in vivo is not known. We have shown that Pin1 ablation is highly effective in preventing...

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Identifiers

PMID: 15257284
DOI: 10.1038/sj.emboj.7600323
PMCID: PMC514501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.PMID 15257284Read ↗

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PIN1 in breast development and cancer: a clinical perspectiveSemantic proximity Read ↗

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Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

The role of Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Targeting Pin1 for Modulation of Cell Motility and Cancer TherapySemantic proximity Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

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