Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.

The Journal of biological chemistry - 6 Jul 2012

Shen Zhong-Jian, Braun Ruedi K, Hu Jie, Xie Qifa, Chu Haiyan, Love Robert B, Stodola Levi A, Rosenthal Louis A, Szakaly Renee J, Sorkness Ronald L, Malter James S

Abstract excerpt

Interstitial pulmonary fibrosis is caused by the excess production of extracellular matrix (ECM) by Fb in response to TGF-β1. Here, we show that the peptidyl-prolyl isomerase Pin1 modulates the production of many pro- and antifibrogenic cytokines and ECM. After acute, bleomycin injury, Pin1(-/-) mice showed reduced, pulmonary expression of collagens, tissue inhibitors of metalloproteinases, and fibrogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Bleomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to NIMA-Interacting Peptidylprolyl Isomerase

Share to Peptidylprolyl Isomerase

Share to Pulmonary Fibrosis

Share to Smad3 Protein

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 22613712
DOI: 10.1074/jbc.M111.313684
PMCID: PMC3390608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.PMID 22613712Read ↗

The Antifibrotic Effects and Mechanisms of MicroRNA-26a Action in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

Cartilage intermediate layer protein attenuates bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad3 negative feedback loopSemantic proximity Read ↗

Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell FunctionSemantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future DirectionsSemantic proximity Read ↗

Direct Delivery of Recombinant Pin1 Protein Rescued Osteoblast Differentiation of Pin1-Deficient Cells.Semantic proximity Read ↗

Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE-/- mice.Semantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

Pin1-mediated Runx2 modification is critical for skeletal development.Semantic proximity Read ↗

Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseasesSemantic proximity Read ↗

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins.Semantic proximity Read ↗

Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loopSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.