Article
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2017
Win Aung Ko, Jenkins Mark A, Dowty James G, Antoniou Antonis C, Lee Andrew, Giles Graham G, Buchanan Daniel D, Clendenning Mark, Rosty Christophe, Ahnen Dennis J, Thibodeau Stephen N, Casey Graham, Gallinger Steven, Le Marchand Loïc, Haile Robert W, Potter John D, Zheng Yingye, Lindor Noralane M, Newcomb Polly A, Hopper John L, MacInnis Robert J
Abstract excerpt
Background: Although high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and MUTYH) account for some familial aggregation of colorectal cancer, their population prevalence and the causes of the remaining familial aggregation are not known.Methods: We studied the families of 5,744 colorectal cancer cases (probands) recruited from population cancer registries in the United...
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