Article
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2017
Yurgelun Matthew B, Kulke Matthew H, Fuchs Charles S, Allen Brian A, Uno Hajime, Hornick Jason L, Ukaegbu Chinedu I, Brais Lauren K, McNamara Philip G, Mayer Robert J, Schrag Deborah, Meyerhardt Jeffrey A, Ng Kimmie, Kidd John, Singh Nanda, Hartman Anne-Renee, Wenstrup Richard J, Syngal Sapna
Abstract excerpt
Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the prevalence of germline cancer susceptibility gene mutations in patients with CRC unselected for high-risk features (eg, early age at diagnosis, personal/family history of cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is unknown. Patients and Methods We recruited 1,058...
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