Article
The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery.
Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2016
Hahn M M, de Voer R M, Hoogerbrugge N, Ligtenberg M J L, Kuiper R P, van Kessel A Geurts
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is a cumulative term applied to a clinically and genetically heterogeneous group of neoplasms that occur in the bowel. Based on twin studies, up to 45 % of the CRC cases may involve a heritable component. Yet, only in 5-10 % of these cases high-penetrant germline mutations are found (e.g. mutations in APC and DNA mismatch repair genes) that result in a familial aggregation...
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