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Article

The missing heritability of familial colorectal cancer

5 Sept 2019

Abstract excerpt

Pinpointing heritability factors is fundamental for the prevention and early detection of cancer. Up to one-quarter of colorectal cancers (CRCs) occur in the context of familial aggregation of this disease, suggesting a strong genetic component. Currently, only less than half of the heritability of CRC can be attributed to hereditary syndromes or common risk loci. Part of the missing heritability of this disease...

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PMID: 31605533
DOI: 10.1093/mutage/gez027

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