Article
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.
Genome biology - 1 Nov 2016
McGovern Amanda, Schoenfelder Stefan, Martin Paul, Massey Jonathan, Duffus Kate, Plant Darren, Yarwood Annie, Pratt Arthur G, Anderson Amy E, Isaacs John D, Diboll Julie, Thalayasingam Nishanthi, Ospelt Caroline, Barton Anne, Worthington Jane, Fraser Peter, Eyre Stephen, Orozco Gisela
Abstract excerpt
BACKGROUND: The identification of causal genes from genome-wide association studies (GWAS) is the next important step for the translation of genetic findings into biologically meaningful mechanisms of disease and potential therapeutic targets. Using novel chromatin interaction detection techniques and allele specific assays in T and B cell lines, we provide compelling evidence that redefines causal genes at the...
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