Article
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
Nature genetics - 1 Dec 2007
Plenge Robert M, Cotsapas Chris, Davies Leela, Price Alkes L, de Bakker Paul I W, Maller Julian, Pe'er Itsik, Burtt Noel P, Blumenstiel Brendan, DeFelice Matt, Parkin Melissa, Barry Rachel, Winslow Wendy, Healy Claire, Graham Robert R, Neale Benjamin M, Izmailova Elena, Roubenoff Ronenn, Parker Alexander N, Glass Roberta, Karlson Elizabeth W, Maher Nancy, Hafler David A, Lee David M, Seldin Michael F, Remmers Elaine F, Lee Annette T, Padyukov Leonid, Alfredsson Lars, Coblyn Jonathan, Weinblatt Michael E, Gabriel Stacey B, Purcell Shaun, Klareskog Lars, Gregersen Peter K, Shadick Nancy A, Daly Mark J, Altshuler David
Abstract excerpt
To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in comparison to publicly available genotype data for 1,211 related individuals from the Framingham Heart Study. After evaluating and adjusting for technical and population biases, we identified a SNP at 6q23 (rs10499194,...
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