Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

PloS one - 1 Jan 2016

Martin Paul, McGovern Amanda, Massey Jonathan, Schoenfelder Stefan, Duffus Kate, Yarwood Annie, Barton Anne, Worthington Jane, Fraser Peter, Eyre Stephen, Orozco Gisela

Abstract excerpt

BACKGROUND: The chromosomal region 6q23 has been found to be associated with multiple sclerosis (MS) predisposition through genome wide association studies (GWAS). There are four independent single nucleotide polymorphisms (SNPs) associated with MS in this region, which spans around 2.5 Mb. Most GWAS variants associated with complex traits, including these four MS associated SNPs, are non-coding and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 6

Share to Computational Biology

Share to Genome-Wide Association Study

Share to Genomics

Share to Multiple Sclerosis

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 27861577
DOI: 10.1371/journal.pone.0166923
PMCID: PMC5115837

Genes

AHI1
BCLAF1
IFNGR1
SGK1
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.PMID 27861577Read ↗

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.Semantic proximity Read ↗

Regulatory genomic regions active in immune cell types explain a large proportion of the genetic risk of multiple sclerosis.Semantic proximity Read ↗

Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effectsSemantic proximity Read ↗

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.Semantic proximity Read ↗

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.Semantic proximity Read ↗

An Intergenic rs9275596 Polymorphism on Chr. 6p21 Is Associated with Multiple Sclerosis in Latvians.Semantic proximity Read ↗

Oligodendroglia as functional effectors of Multiple Sclerosis risk variantsSemantic proximity Read ↗

Functional relevance for multiple sclerosis-associated genetic variants.Semantic proximity Read ↗

Utilising multi-large omics data to elucidate biological mechanisms within multiple sclerosis genetic susceptibility loci.Semantic proximity Read ↗

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.Semantic proximity Read ↗

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.Semantic proximity Read ↗

DNase hypersensitive sites and association with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.