Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

doi:10.1038/ng.766

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Article

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

Nature genetics - 1 Mar 2011

Adrianto Indra, Wen Feng, Templeton Amanda, Wiley Graham, King Jarrod B, Lessard Christopher J, Bates Jared S, Hu Yanqing, Kelly Jennifer A, Kaufman Kenneth M, Guthridge Joel M, Alarcón-Riquelme Marta E, Anaya Juan-Manuel, Bae Sang-Cheol, Bang So-Young, Boackle Susan A, Brown Elizabeth E, Petri Michelle A, Gallant Caroline, Ramsey-Goldman Rosalind, Reveille John D, Vila Luis M, Criswell Lindsey A, Edberg Jeffrey C, Freedman Barry I, Gregersen Peter K, Gilkeson Gary S, Jacob Chaim O, James Judith A, Kamen Diane L, Kimberly Robert P, Martin Javier, Merrill Joan T, Niewold Timothy B, Park So-Yeon, Pons-Estel Bernardo A, Scofield R Hal, Stevens Anne M, Tsao Betty P, Vyse Timothy J, Langefeld Carl D, Harley John B, Moser Kathy L, Webb Carol F, Humphrey Mary Beth, Montgomery Courtney Gray, Gaffney Patrick M

Abstract excerpt

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE. By fine mapping and genomic...

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Identifiers

PMID: 21336280
DOI: 10.1038/ng.766
PMCID: PMC3103780

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21336280-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.PMID 21336280Read ↗

An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.Semantic proximity Read ↗

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Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read ↗

Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read ↗

Large-scale DNA sequencing identifies rare variants associated with Systemic Lupus Erythematosus susceptibility in known risk genes.Semantic proximity Read ↗

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The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

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