Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases.

Genes and immunity - 1 Apr 2011

Musone S L, Taylor K E, Nititham J, Chu C, Poon A, Liao W, Lam E T, Ma A, Kwok P-Y, Criswell L A

Abstract excerpt

The TNFAIP3 locus at 6q23, encoding A20, has been associated with multiple autoimmune diseases (AIDs). In this study, we sequence the coding portions of the gene to identify contributing causal polymorphisms that may explain some of the observed associations. A collection of 123 individuals from the Multiple Autoimmune Disease Genetics Consortium (MADGC) collection, each with multiple AIDs (mean=2.2 confirmed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Autoimmune Diseases
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Gene Frequency

Share to Intracellular Signaling Peptides and Proteins

Share to Nuclear Proteins

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 21326317
DOI: 10.1038/gene.2010.64
PMCID: PMC3152744

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases.PMID 21326317Read ↗

Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.Semantic proximity Read ↗

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.Semantic proximity Read ↗

Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases.Semantic proximity Read ↗

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.Semantic proximity Read ↗

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.Semantic proximity Read ↗

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.Semantic proximity Read ↗

Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome.Semantic proximity Read ↗

Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet’s diseaseSemantic proximity Read ↗

Identification of a Novel Mutation in TNFAIP3 in a Family With Poly-Autoimmunity.Semantic proximity Read ↗

A novel missense mutation in TNFAIP3 causes haploinsufficiency of A20.Semantic proximity Read ↗

Case Report: A novel mutation in TNFAIP3 in a patient with type 1 diabetes mellitus and haploinsufficiency of A20.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.