Article
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Nature genetics - 1 Dec 2012
Eyre Steve, Bowes John, Diogo Dorothée, Lee Annette, Barton Anne, Martin Paul, Zhernakova Alexandra, Stahl Eli, Viatte Sebastien, McAllister Kate, Amos Christopher I, Padyukov Leonid, Toes Rene E M, Huizinga Tom W J, Wijmenga Cisca, Trynka Gosia, Franke Lude, Westra Harm-Jan, Alfredsson Lars, Hu Xinli, Sandor Cynthia, de Bakker Paul I W, Davila Sonia, Khor Chiea Chuen, Heng Khai Koon, Andrews Robert, Edkins Sarah, Hunt Sarah E, Langford Cordelia, Symmons Deborah, Concannon Pat, Onengut-Gumuscu Suna, Rich Stephen S, Deloukas Panos, Gonzalez-Gay Miguel A, Rodriguez-Rodriguez Luis, Ärlsetig Lisbeth, Martin Javier, Rantapää-Dahlqvist Solbritt, Plenge Robert M, Raychaudhuri Soumya, Klareskog Lars, Gregersen Peter K, Worthington Jane
Abstract excerpt
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European ancestry and 15,870 controls for 129,464 markers. We combined these data in a meta-analysis with GWAS data from additional independent cases (n = 2,363) and controls (n = 17,872). We...
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