Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.

PLoS genetics - 1 Jan 2013

Wang Shaofeng, Wen Feng, Wiley Graham B, Kinter Michael T, Gaffney Patrick M

Abstract excerpt

Functional characterization of causal variants present on risk haplotypes identified through genome-wide association studies (GWAS) is a primary objective of human genetics. In this report, we evaluate the function of a pair of tandem polymorphic dinucleotides, 42 kb downstream of the promoter of TNFAIP3, (rs148314165, rs200820567, collectively referred to as TT>A) recently nominated as causal variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic
Share to HEK293 Cells
Share to Intracellular Signaling Peptides and Proteins
Share to Lupus Erythematosus, Systemic
Share to Matrix Attachment Region Binding Proteins
Share to NF-kappa B
Share to Nuclear Proteins
Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 24039598
DOI: 10.1371/journal.pgen.1003750
PMCID: PMC3764111

Genes

TNFAIP3
SATB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.PMID 24039598Read ↗

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.Semantic proximity Read ↗

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.Semantic proximity Read ↗

TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus.Semantic proximity Read ↗

Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.Semantic proximity Read ↗

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.Semantic proximity Read ↗

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read ↗

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read ↗

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.Semantic proximity Read ↗

Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.