Article

DUETT quantitatively identifies known and novel events in nascent RNA structural dynamics from chemical probing data

2018-11-01

Abstract excerpt

<h4>Motivation</h4> RNA molecules can undergo complex structural dynamics, especially during transcription, which influence their biological functions. Recently developed high-throughput chemical probing experiments study RNA cotranscriptional folding to generate nucleotide-resolution ‘reactivities’ for each length of a growing nascent RNA and reflect structural dynamics. However, the manual annotation and qualit...

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Literature Corpus work: abacc449-fefb-584e-8588-5b5b84c9bc97
DOI: 10.1101/458703

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