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Article

Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2012

Perdrizet George A, Artsimovitch Irina, Furman Ran, Sosnick Tobin R, Pan Tao

Abstract excerpt

Riboswitches are cis-acting elements that regulate gene expression by affecting transcriptional termination or translational initiation in response to binding of a metabolite. A typical riboswitch is made of an upstream aptamer domain and a downstream expression platform. Both domains participate in the folding and structural rearrangement in the absence or presence of its cognate metabolite. RNA polymerase...

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Share to Aptamers, Nucleotide
Share to Inverted Repeat Sequences

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Osmolar Concentration

Share to Peptide Chain Initiation, Translational

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Source

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Identifiers

PMID: 22331895
DOI: 10.1073/pnas.1113086109
PMCID: PMC3295289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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