Article
Tuning strand displacement kinetics enables programmable ZTP riboswitch dynamic range in vivo.
Nucleic acids research - 11 Apr 2023
Bushhouse David Z, Lucks Julius B
Abstract excerpt
A large body of work has shown that transcriptional riboswitches function through internal strand displacement mechanisms that guide the formation of alternative structures which drive regulatory outcomes. Here, we sought to investigate this phenomenon using the Clostridium beijerinckii pfl ZTP riboswitch as a model system. Using functional mutagenesis with Escherichia coli gene expression assays, we show that...
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