Article

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

2021-02-23

Abstract excerpt

Elucidating the molecular basis of immunodeficiency diseases is a powerful approach to discovering new immunoregulatory pathways in humans. Here we report 10 affected individuals from 4 families with a new immunodeficiency disease comprising of severe progressive lymphopenia, autoimmunity, immunodeficiency, and liver disease due to recessive loss of function variants in “GTPase of immunity-associated proteins” pr...

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Literature Corpus work: b08e35f2-564b-5848-8098-c2a37863e1e6
DOI: 10.1101/2021.02.22.432146

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