Article
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 11 May 2010
Rodriguez-Manzanet Roselynn, Sanjuan Miguel A, Wu Henry Y, Quintana Francisco J, Xiao Sheng, Anderson Ana C, Weiner Howard L, Green Douglas R, Kuchroo Vijay K
Abstract excerpt
TIM-4, a member of the TIM family expressed on antigen-presenting cells, binds to phosphatidylserine exposed on the surface of apoptotic bodies. However, the significance of this interaction in vivo remains unknown because other receptors have been implicated in the clearance of apoptotic bodies and could compensate for the TIM-4 deficiency in vivo. In this study, we describe the generation of TIM-4-deficient...
Topics
- Animals
- Antibodies, Antinuclear
- Antigen-Presenting Cells
- Apoptosis
- Autoimmunity
- B-Lymphocytes
- Cell Compartmentation
- Female
- Lymphocyte Activation
- Macrophages, Peritoneal
- Male
- Membrane Proteins