Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CHOP Mediates Endoplasmic Reticulum Stress-Induced Apoptosis in Gimap5-Deficient T Cells

7 May 2009

Abstract excerpt

Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap5 gene that leads to spontaneous apoptosis of peripheral T cells by an unknown mechanism. Because Gimap5 localizes to the endoplasmic reticulum (ER), we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19424493
DOI: 10.1371/journal.pone.0005468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHOP Mediates Endoplasmic Reticulum Stress-Induced Apoptosis in Gimap5-Deficient T CellsPMID 19424493Read ↗

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.Semantic proximity Read ↗

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.Semantic proximity Read ↗

The GIMAP Family Proteins: An Incomplete Puzzle.Semantic proximity Read ↗

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.Semantic proximity Read ↗

GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.Semantic proximity Read ↗

Sequence variation and expression of the Gimap gene family in the BB rat.Semantic proximity Read ↗

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.Semantic proximity Read ↗

ER chaperones in mammalian development and human diseasesSemantic proximity Read ↗

Unfolded protein responses in T cell immunitySemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.Semantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.