Article
GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.
The Biochemical journal - 15 Jan 2013
Chen Xi Lin, Serrano Daniel, Mayhue Marian, Wieden Hans-Joachim, Stankova Jana, Boulay Guylain, Ilangumaran Subburaj, Ramanathan Sheela
Abstract excerpt
Mature T-lymphocytes undergo spontaneous apoptosis in the biobreeding diabetes-prone strain of rats due to the loss of the functional GIMAP5 (GTPase of the immune-associated nucleotide-binding protein 5) protein. The mechanisms underlying the pro-survival function of GIMAP5 in T-cells have not yet been elucidated. We have previously shown that GIMAP5 deficiency in T-cells impairs Ca2+ entry via plasma membrane...
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