Article
Bcl-2 supports survival and metabolic fitness of quiescent tissue-resident ILC3.
Mucosal immunology - 1 Oct 2023
King James I, Melo-Gonzalez Felipe, Malengier-Devlies Bert, Tachó-Piñot Roser, Magalhaes Marlene S, Hodge Suzanne H, Romero Ros Xavier, Gentek Rebecca, Hepworth Matthew R
Abstract excerpt
Group 3 innate lymphoid cells (ILC3) are potent effector cells with critical roles in enforcing immunity, barrier integrity and tissue homeostasis along the gastrointestinal tract. ILC3 are considered primarily tissue-resident cells, seeding the gastrointestinal tract during embryonic stages and early life. However, the mechanisms through which mature ILC3 are maintained within adult tissues are poorly...
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