Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.

European heart journal - 7 Feb 2016

Tada Hayato, Melander Olle, Louie Judy Z, Catanese Joseph J, Rowland Charles M, Devlin James J, Kathiresan Sekar, Shiffman Dov

Abstract excerpt

AIMS: Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS (GRS27) to a 50-variant GRS (GRS50) improved CHD prediction and whether GRSs are independent of self-reported family history of CHD. METHODS AND RESULTS: The association between GRSs and incident CHD was assessed in Cox models adjusting for established...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to Epidemiologic Methods

Share to Genetic Predisposition to Disease

Share to Pedigree

Share to Polymorphism, Single Nucleotide

Share to Sweden

Source

Open in PubMed Open full text

Identifiers

PMID: 26392438
DOI: 10.1093/eurheartj/ehv462
PMCID: PMC4744619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.PMID 26392438Read ↗

A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study.Semantic proximity Read ↗

Genomic prediction of coronary heart disease.Semantic proximity Read ↗

Metabolic Mediators of the Effects of Family History and Genetic Risk Score on Coronary Heart Disease-Findings From the Malmö Diet and Cancer Study.Semantic proximity Read ↗

How close are we to implementing a genetic risk score for coronary heart disease?Semantic proximity Read ↗

Genomic prediction of coronary heart diseaseSemantic proximity Read ↗

Incremental predictive value of 152 single nucleotide polymorphisms in the 10-year risk prediction of incident coronary heart disease: the Rotterdam Study.Semantic proximity Read ↗

Assessment of the value of a genetic risk score in improving the estimation of coronary risk.Semantic proximity Read ↗

Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.Semantic proximity Read ↗

Assessment of the clinical utility of adding common single nucleotide polymorphism genetic scores to classical risk factor algorithms in coronary heart disease risk prediction in UK men.Semantic proximity Read ↗

Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 000 Individuals of European Ancestry.Semantic proximity Read ↗

Association between parental history and genetic risk scores for coronary heart disease prediction: The population-based CoLaus study.Semantic proximity Read ↗

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary preventionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.