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Article

An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.

Journal of pharmaceutical sciences - 1 Dec 2016

Xia Xue, Kumru Ozan S, Blaber Sachiko I, Middaugh C Russell, Li Ling, Ornitz David M, Suh Jae Myoung, Atkins Annette R, Downes Michael, Evans Ronald M, Tenorio Connie A, Bienkiewicz Ewa, Blaber Michael

Abstract excerpt

Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S116) has been proposed to regulate intracrine signaling. Position S116 is located within a ∼17 amino acid C-terminal loop that contains a rich set of functional...

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Identifiers

PMID: 27773526
DOI: 10.1016/j.xphs.2016.09.005
PMCID: PMC5310217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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