Article
The D647N mutation of FGFR1 induces ligand-independent receptor activation.
Biochimica et biophysica acta. General subjects - 1 Dec 2023
Domenichini Mattia, Ravelli Cosetta, Corsini Michela, Codenotti Silvia, Moreschi Elisa, Gogna Anna, Capoferri Davide, Zizioli Daniela, Bresciani Roberto, Grillo Elisabetta, Mitola Stefania
Abstract excerpt
The activation loop (A-loop) of kinases, a key regulatory region, is recurrently mutated in several kinase proteins in cancer resulting in dysregulated kinase activity and response to kinase inhibitors. FGFR1 receptor tyrosine kinase represents an important oncogene and therapeutic target for solid and hematological tumors. Here we investigate the biochemical and molecular effects of D647N mutation lying in the...
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