Article
Charge reversal in the heparin-binding pocket enhances the stability and activity of the human FGF1.
Biophysical journal - 4 Aug 2026
Davis Julie Eberle, Kerr Rebecca, Hettige Jeevapani J, Sonnaila Shivakumar, Badiee Shadi A, Kumar Gayatri Suresh, Agrawal Shilpi, Koppulu Bhanuprashanth, Jayanthi Srinivas, A Zaharoff David, Moradi Mahmoud, Suresh Kumar Thallapuranam Krishnaswamy
Abstract excerpt
Human fibroblast growth factor 1 (hFGF1) is a potent signaling molecule whose role in cell growth, differentiation, and migration has made it an excellent candidate for wide-ranging biomedical applications. hFGF1 binds heparan sulfate proteoglycans, which stabilize the protein and play a crucial role in growth factor-induced signaling. Within the heparin-binding region of hFGF1 lies a thrombin cleavage site at...
Topics
- Fibroblast Growth Factor 1
- Humans
- Heparin
- Protein Stability
- Binding Sites
- Molecular Dynamics Simulation
- Static Electricity
- Mutation