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Article

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.

Journal of molecular biology - 30 Sept 2005

Zakrzewska Malgorzata, Krowarsch Daniel, Wiedlocha Antoni, Olsnes Sjur, Otlewski Jacek

Abstract excerpt

Fibroblast growth factor 1 (FGF-1) shows strong angiogenic, osteogenic and tissue-injury repair properties that might be relevant to medical applications. Since FGF-1 is partially unfolded at physiological temperature we decided to increase significantly its conformational stability and test how such an improvement will affect its biological function. Using an homology approach and rational strategy we designed...

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Identifiers

PMID: 16126225
DOI: 10.1016/j.jmb.2005.07.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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