Article
ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.
Science signaling - 12 Feb 2013
Zakrzewska Malgorzata, Haugsten Ellen Margrethe, Nadratowska-Wesolowska Beata, Oppelt Angela, Hausott Barbara, Jin Yixin, Otlewski Jacek, Wesche Jørgen, Wiedlocha Antoni
Abstract excerpt
Fibroblast growth factor 1 (FGF1) controls cellular activities through the activation of specific cell-surface FGF receptors (FGFRs). Transphosphorylation of tyrosine residues in the kinase domain of FGFRs leads to activation of intracellular signaling cascades, including those mediated by mitogen-activated protein kinases (MAPKs). FGFRs also contain a serine-rich C-terminal tail. We identified a regulatory...
Topics
- Amino Acid Sequence
- Animals
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Receptor, Fibroblast Growth Factor, Type 1
- Sequence Homology, Amino Acid
- Serine
- Signal Transduction