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Article

Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes.

PloS one - 1 Jan 2016

van Essen T Huibertus, van Pelt Sake I, Bronkhorst Inge H G, Versluis Mieke, Némati Fariba, Laurent Cécile, Luyten Gregorius P M, van Hall Thorbald, van den Elsen Peter J, van der Velden Pieter A, Decaudin Didier, Jager Martine J

Abstract excerpt

INTRODUCTION: Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an increased risk of death due to metastases. These tumors should be ideal for T-cell based therapies, yet it is not clear why prognostically-infaust tumors have a high HLA expression. We set out to determine whether the level of HLA molecules in...

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Share to Chromosomes, Human, Pair 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

Share to Mice, SCID

Share to Neoplasm Metastasis

Share to Transplantation, Heterologous

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Source

Open in PubMed Open full text

Identifiers

PMID: 27764126
DOI: 10.1371/journal.pone.0164292
PMCID: PMC5072555

Genes

CIITA
NLRC5
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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