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HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma

9 Dec 2020

Abstract excerpt

The treatment of uveal melanoma (UM) metastases or adjuvant treatment may imply immunological approaches or chemotherapy. It is to date unknown how epigenetic modifiers affect the expression of immunologically relevant targets, such as the HLA Class I antigens, in UM. We investigated the expression of HDACs and the histone methyl transferase EZH2 in a set of 64 UMs, using an Illumina HT12V4 array, and determined...

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PMID: 33316946
DOI: 10.3390/cancers12123690

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