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Article

LAG3 and Its Ligands Show Increased Expression in High-Risk Uveal Melanoma

3 Sept 2021

Abstract excerpt

Uveal melanoma (UM) is a rare ocular malignancy which originates in the uveal tract, and often gives rise to metastases. Potential targets for immune checkpoint inhibition are lymphocyte-activation gene 3 (LAG3) and its ligands. We set out to analyse the distribution of these molecules in UM. The expression of mRNA was determined using an Illumina array in 64 primary UM from Leiden. The T lymphocyte fraction was...

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PMID: 34503258
DOI: 10.3390/cancers13174445

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