Article
A comparison of HLA genotype with inflammation in uveal melanoma.
Investigative ophthalmology & visual science - 4 May 2012
van Essen T Huibertus, Bronkhorst Inge H G, Maat Willem, Verduyn Willem, Roelen Dave L, Luyten Gregorius P M, Jager Martine J
Abstract excerpt
PURPOSE: Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy. The goal of our study was to determine whether specific HLA alleles are associated with...
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