Article
Normal HLA class I, II, and MICA gene distribution in uveal melanoma.
Molecular vision - 21 Dec 2005
Metzelaar-Blok J A W, Hurks H M H, Naipal A, De Lange P, Keunen J E E, Claas F H J, Doxiadis I I N, Jager M J
Abstract excerpt
PURPOSE: The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility contributed by HLA class I, class II, or MICA genes with regard to the development of uveal melanoma....
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