Article
Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma.
Oncotarget - 10 Nov 2015
de Lange Mark J, van Pelt Sake I, Versluis Mieke, Jordanova Ekaterina S, Kroes Wilma G M, Ruivenkamp Claudia, van der Burg Sjoerd H, Luyten Grégorius P M, van Hall Thorbald, Jager Martine J, van der Velden Pieter A
Abstract excerpt
Gene expression profiles as well as genomic imbalances are correlated with disease progression in uveal melanoma (UM). We integrated expression and genomic profiles to obtain insight into the oncogenic mechanisms in development and progression of UM. We used tumor tissue from 64 enucleated eyes of UM patients for profiling. Mutations and genomic imbalances were quantified with digital PCR to study tumor...
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