Article
Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.
Menopause (New York, N.Y.) - 1 Feb 2017
Pasquale Louis R, Aschard Hugues, Kang Jae H, Bailey Jessica N Cooke, Lindström Sara, Chasman Daniel I, Christen William G, Allingham R Rand, Ashley-Koch Allison, Lee Richard K, Moroi Sayoko E, Brilliant Murray H, Wollstein Gadi, Schuman Joel S, Fingert John, Budenz Donald L, Realini Tony, Gaasterland Terry, Gaasterland Douglas, Scott William K, Singh Kuldev, Sit Arthur J, Igo Robert P, Song Yeunjoo E, Hark Lisa, Ritch Robert, Rhee Douglas J, Gulati Vikas, Havens Shane, Vollrath Douglas, Zack Donald J, Medeiros Felipe, Weinreb Robert N, Pericak-Vance Margaret A, Liu Yutao, Kraft Peter, Richards Julia E, Rosner Bernard A, Hauser Michael A, Haines Jonathan L, Wiggs Janey L
Abstract excerpt
OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Using data from the Nurses' Health Study (7,143 women), we validated the ANM weighted genetic risk score in relation to...
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