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Identifying potential causal effects of age at menopause: a Mendelian randomization phenome-wide association study.

European journal of epidemiology - 1 Sept 2022

Magnus Maria C, Borges Maria Carolina, Fraser Abigail, Lawlor Deborah A

Abstract excerpt

Age at natural menopause (ANM) is associated with a range of health-related traits, including bone health, female reproductive cancers, and cardiometabolic health. Our objective was to conduct a Mendelian randomization phenome-wide association study (MR-pheWAS) of ANM. We conducted a hypothesis-free analysis of the genetic risk score (GRS) for ANM with 18,961 health-related traits among 181,279 women in UK...

Topics

Breast Neoplasms
Cardiovascular Diseases
Female
Genome-Wide Association Study
Glycated Hemoglobin
Humans
Male
Mendelian Randomization Analysis
Menopause
Minerals
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 36057072
DOI: 10.1007/s10654-022-00903-3
PMCID: PMC9529691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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