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Article

Causal factors in primary open angle glaucoma: a phenome-wide Mendelian randomisation study.

Scientific reports - 20 Jun 2023

Julian Thomas H, Girach Zain, Sanderson Eleanor, Guo Hui, Yu Jonathan, Cooper-Knock Johnathan, Black Graeme C, Sergouniotis Panagiotis I

Abstract excerpt

Primary open angle glaucoma (POAG) is a chronic, adult-onset optic neuropathy associated with characteristic optic disc and/or visual field changes. With a view to identifying modifiable risk factors for this common neurodegenerative condition, we performed a 'phenome-wide' univariable Mendelian randomisation (MR) study that involved analysing the relationship between 9661 traits and POAG. Utilised analytical...

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Identifiers

PMID: 37340071
DOI: 10.1038/s41598-023-37144-7
PMCID: PMC10282034

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