Article
The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.
Haematologica - 1 Feb 2017
Gangadharan Bagirath, Ing Mathieu, Delignat Sandrine, Peyron Ivan, Teyssandier Maud, Kaveri Srinivas V, Lacroix-Desmazes Sébastien
Abstract excerpt
The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with receptor(s) on antigen-presenting cells, followed by endocytosis and presentation to naïve CD4+ T cells. Recent studies indicate a role for the C1 domain in factor...
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