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Article

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

The Journal of biological chemistry - 11 Oct 2013

Bloem Esther, van den Biggelaar Maartje, Wroblewska Aleksandra, Voorberg Jan, Faber Johan H, Kjalke Marianne, Stennicke Henning R, Mertens Koen, Meijer Alexander B

Abstract excerpt

The C1 domain of factor VIII (FVIII) has been implicated in binding to multiple constituents, including phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP). We have previously described a human monoclonal antibody called KM33 that blocks these interactions as well as cellular uptake by LRP-expressing cells. To unambiguously identify the apparent "hot spot" on FVIII to...

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Deuterium Exchange Measurement
Endocytosis
Factor VIII
LDL-Receptor Related Proteins
Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylserines

Surface Plasmon Resonance

von Willebrand Factor

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Identifiers

PMID: 24009077
DOI: 10.1074/jbc.M113.473116
PMCID: PMC3795264

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