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Article

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.

Blood - 17 Mar 2011

Lü Junhong, Pipe Steven W, Miao Hongzhi, Jacquemin Marc, Gilbert Gary E

Abstract excerpt

Factor VIII binds to phosphatidylserine (PS)-containing membranes through its tandem, lectin-homology, C1 and C2 domains. However, the details of C1 domain membrane binding have not been delineated. We prepared 4 factor VIII C1 mutations localized to a hypothesized membrane-interactive surface (Arg2090Ala/Gln2091Ala, Lys2092Ala/Phe2093Ala, Gln2042Ala/Tyr2043Ala, and Arg2159Ala). Membrane binding and cofactor...

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Amino Acids
Cysteine Endopeptidases
Factor VIII
Factor X
Mutant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Surface Properties

von Willebrand Factor

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PMID: 21156843
DOI: 10.1182/blood-2010-08-301663

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A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.PMID 21156843Read ↗

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