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Article

Removal of Mannose-Ending Glycan at Asn2118 Abrogates FVIII Presentation by Human Monocyte-Derived Dendritic Cells.

Frontiers in immunology - 1 Jan 2020

Delignat Sandrine, Rayes Julie, Dasgupta Suryasarathi, Gangadharan Bagirath, Denis Cécile V, Christophe Olivier D, Bayry Jagadeesh, Kaveri Srinivas V, Lacroix-Desmazes Sébastien

Abstract excerpt

The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on human dendritic cells, thereby leading to factor VIII endocytosis and presentation to CD4+ T lymphocytes. Here, we investigated whether altering the interaction of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32273875
DOI: 10.3389/fimmu.2020.00393
PMCID: PMC7117063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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