Functional mapping of the A2 domain from human factor VIII.

doi:10.1160/TH11-07-0492

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Article

Functional mapping of the A2 domain from human factor VIII.

Thrombosis and haemostasis - 1 Feb 2012

Plantier Jean-Luc, Saboulard Didier, Pellequer Jean-Luc, Négrier Claude, Delcourt Marc

Abstract excerpt

Coagulation factor VIII (FVIII) is a multidomain glycoprotein in which the FVIII A2 domain is a key structural element. We aimed at identifying residues within FVIII A2 domain that are crucial for the maintenance of the cofactor function. A high number (n=206) of mutants were generated by substituting original residues with alanine. The mutants were expressed in COS-1 cells and their antigen levels and...

Topics

Amino Acid Sequence
Animals
Blood Coagulation
COS Cells
Chlorocebus aethiops
Cricetinae
Factor VIII
Hemophilia A
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutant Proteins
Mutation
Peptide Fragments
Protein Structure, Tertiary

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Open in PubMed

Identifiers

PMID: 22234396
DOI: 10.1160/TH11-07-0492

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