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Article

Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2010

Plantier J L, Rolli V, Ducasse C, Dargaud Y, Enjolras N, Boukerche H, Négrier C

Abstract excerpt

BACKGROUND: Factor VIII (FVIII) and its activated form (FVIIIa) are subject to proteolysis that dampens their cofactor function. Among the proteases that attack FVIII (activated factor X (FXa), activated protein C (APC) and plasmin), only APC cleaves within the FVIII A2 domain at R562 to fully abolish FVIII activity. OBJECTIVES: We investigated the possible involvement of the FXa cleavage at R562 within the A2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19874476
DOI: 10.1111/j.1538-7836.2009.03675.x

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APC

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