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Article

Functional mapping of factor VIII C2 domain.

Thrombosis and haemostasis - 1 Jul 2011

Pellequer Jean-Luc, Chen Shu-wen W, Saboulard Didier, Delcourt Marc, Négrier Claude, Plantier Jean-Luc

Abstract excerpt

The factor VIII (FVIII) is a cofactor of the coagulation cascade. The FVIII C2 domain is a critical domain that participates in the interactions with the von Willebrand factor and the phospholipidic surfaces. To assess the importance of each residue of this domain in the maintenance of the structure and the function of FVIII, a number (n=139) of mutants were generated by substituting the original residues, from...

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Identifiers

PMID: 21614407
DOI: 10.1160/TH10-09-0572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional mapping of factor VIII C2 domain.PMID 21614407Read ↗

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