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Article

Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.

Molecular pharmacology - 1 Dec 2016

Sato Seiji, Huang Xi-Ping, Kroeze Wesley K, Roth Bryan L

Abstract excerpt

In this study, we identified two previously described kinase inhibitors-3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine (LY2784544) and 1H-benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)- (GSK2636771)-as novel GPR39 agonists by unbiased small-molecule-based screening using a β-arrestin...

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Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Source

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Identifiers

PMID: 27754899
DOI: 10.1124/mol.116.106112
PMCID: PMC5118639

Genes

GPR39

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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