Article

In Silico Identification and Characterization of Spiro [1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α Modulators

2025-04-18

Abstract excerpt

This study unveils a new class of spiro[1,2,4]triazolo[1,5-c]quinazoline derivatives as promising diacylglycerol kinase α (DGKα) modulators, a target implicated in cancer, neurological disorders, and immune dysfunction. Through structure-based computational design using the CB-Dock2 platform with human DGKα EF-hand domains (PDB ID: 6IIE), 40 novel compounds were systematically evaluated along established inhibitor...

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Literature Corpus work: 010e1544-9a43-5cb1-abfe-670f228bcdd7
DOI: 10.20944/preprints202504.1554.v1

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In Silico Identification and Characterization of Spiro [1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α ModulatorsDOI 10.20944/preprints202504.1554.v1Read

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