Article
Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
Bioscience, biotechnology, and biochemistry - 1 Dec 2020
Kawamura Tatsuro, Futamura Yushi, Shang Erchang, Muroi Makoto, Janning Petra, Ueno Masayoshi, Wilke Julian, Takeda Shigeki, Kondoh Yasumitsu, Ziegler Slava, Watanabe Nobumoto, Waldmann Herbert, Osada Hiroyuki
Abstract excerpt
Discovery of small-molecule inducers of unique phenotypic changes combined with subsequent target identification often provides new insights into cellular functions. Here, we applied integrated profiling based on cellular morphological and proteomic changes to compound screening. We identified an indane derivative, NPD9055, which is mechanistically distinct from reference compounds with known modes of action....
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